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Target intelligence / Profile preview
BTB and CNC homology 1 (BACH1)
- Target
- BACH1
- Molecular classification
- Transcription factor, bZip transcription factor
01
Overview
BTB and CNC homology 1 (BACH1) is a transcription factor that functions as both a transcriptional repressor and activator, depending on cellular context. It is involved in various biological processes, including heme homeostasis, redox regulation, cell cycle control, hematopoiesis, and immunity. Dysregulation of BACH1 has been implicated in diseases such as acute myeloid leukemia, breast cancer, neurodegenerative diseases, and ferroptosis. It interacts with small Maf proteins and pluripotency factors.
02
Biological functions
Heme homeostasisRedox regulationCell cycleApoptosisHematopoiesisImmunitySubcellular transport
03
Disease associations
Acute myeloid leukemiaBreast cancerEndothelial inflammationNeurodegenerative diseaseFerroptosisCancer
04
Safety considerations
Therapeutic targeting must be tailored due to its diverse roles across tissues/diseases
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