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Target intelligence / Profile preview
BTB domain and CNC homolog 1 (BACH1)
- Target
- BACH1
- Molecular classification
- Transcription factor
01
Overview
BACH1 is a transcriptional repressor that plays a role in oxidative stress response, heme metabolism, and cell cycle control. It negatively regulates gene expression by binding to Maf recognition elements. In cancer, it can promote tumor invasion and influence sensitivity to ferroptosis.
02
Mechanism of action
Transcriptional repression
03
Biological functions
Negative regulation of transcription by RNA polymerase IIRegulation of DNA-templated transcriptionOxidative stress responseHeme metabolismCell cycle controlDNA repair
04
Disease associations
Fanconi AnemiaBeta ThalassemiaCancer
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