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Target intelligence / Profile preview
BTG anti-proliferation factor 4 (BTG4)
- Target
- BTG4
- Molecular classification
- Other (adapter protein, not a classical receptor/enzyme/transcription factor), BTG/Tob family
01
Overview
BTG anti-proliferation factor 4 (BTG4) is an adapter protein in the BTG/Tob family with anti-proliferative properties. It bridges CNOT7, a component of the CCR4-NOT deadenylase complex, to EIF4E and is essential for maternal mRNA decay during oocyte and early embryonic development. BTG4 plays a critical role in the maternal-zygotic transition, cell cycle arrest at G1, and the initiation of embryonic development. Mutations in the BTG4 gene are associated with reproductive disorders such as premature ovarian failure and maturation arrest of oocytes, zygotes, or embryos.
- Other names
- Protein BTG4PC3BAPRO3BTG family member 4Protein PC3bOOMD8OZEMA8B-cell translocation gene 4
02
Biological functions
Maternal mRNA decay during oocyte maturation and fertilizationCell cycle arrest (G1 arrest)Regulation of RNA metabolism through mRNA deadenylationRequired for maternal-zygotic transition and early embryonic development
03
Disease associations
Premature ovarian failureOocyte/zygote/embryo maturation arrest
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