BUB1B-PAK6 readthrough (BUB1B-PAK6)

BUB1B-PAK6 readthrough is a **readthrough transcription event** in Homo sapiens that joins exonic sequences from the upstream *BUB1B* gene (mitotic checkpoint serine/threonine-protein kinase BUB1 beta) and the downstream *PAK6* gene (serine/threonine-protein kinase PAK6). The resulting transcript encodes a protein that is indistinguishable in sequence and function from the standard PAK6 protein, with no unique protein product or biological activity attributed to the readthrough event itself. The significance of this gene is largely limited to genome annotation and does not represent a distinct therapeutic target, molecular family, or biological function. Canonical functions and disease relevance should be mapped to the separate genes BUB1B (involved in mitotic checkpoint regulation and linked to mosaic variegated aneuploidy and cancer predisposition) and PAK6 (a kinase involved in cytoskeletal signaling and potentially cancer), but not to the BUB1B-PAK6 readthrough product itself. No drugs, biomarkers, or safety considerations are known for the readthrough as an independent entity. **Note:** - This is not a therapeutically relevant gene target, but a genome annotation artifact from readthrough transcription. For any meaningful biological or pharmacological information, refer to BUB1B or PAK6 as individual gene entries. - The readthrough does not encode a unique protein; thus, any references to therapeutic targeting, biology, or druggability should be attributed to PAK6 or BUB1B and not to this readthrough.

Other names

PAK6PAK-6PAK5 (less common, may represent a misidentification)BUB1B-PAK6 readthrough