BUD13 homolog pseudogene 1 (BUD13P1)

BUD13 homolog pseudogene 1 (abbreviated BUD13P1) is classified as a pseudogene in the human genome[3]. Unlike protein-coding genes, pseudogenes such as BUD13P1 do not encode functional proteins and are generally regarded as nonfunctional genomic elements. BUD13P1 is related by sequence similarity to BUD13 homolog, a component of the retention and splicing (RES) complex involved in RNA splicing in yeast and humans, but there is no evidence that BUD13P1 itself codes for a functional protein or plays any direct role in molecular or cellular processes[3][5]. BUD13, the functional gene/protein (not the pseudogene), has been studied for its role in mRNA splicing and diseases such as glioblastoma and metabolic disorders[1][6]. However, BUD13P1 is distinct and lacks evidence of function or disease association. No drugs, mechanisms of action, or biomarker roles are known for BUD13P1. The nomenclature or reference to "BUD13P1" as a therapeutic target is incorrect, as its classification as a pseudogene excludes it from conventional drug target or biomarker status. BUD13 homolog pseudogene 1 (BUD13P1) is a non-coding pseudogene with no known function, disease associations, or therapeutic relevance. Any implication that it is a protein-coding target is incorrect[3][5].