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Target intelligence / Profile preview
Budding Uninhibited by Benzimidazoles 1 Kinase (BUB1)
- Target
- BUB1
- Molecular classification
- Enzyme, Serine/threonine kinase, Protein kinase
01
Overview
Budding uninhibited by benzimidazoles 1 kinase (BUB1) is a serine/threonine protein kinase that plays a central role in the mitotic spindle assembly checkpoint (SAC) and chromosome congression during cell division. It ensures accurate chromosome segregation during mitosis by stabilizing kinetochore-microtubule attachments and preventing premature progression into anaphase. Overexpression or dysregulation of BUB1 has been linked with various cancers and high levels often correlate with poor prognosis.
- Other names
- Mitotic checkpoint serine/threonine-protein kinase BUB1hBUB11hBub11A/Bub11L
02
Biological functions
Cell cycleSpindle assembly checkpointChromosome segregationKinetochore-microtubule attachment stabilizationTGFβ signalingTelomere DNA replicationDNA damage responseRegulation of endocytosisViral entry
03
Disease associations
CancerLung adenocarcinoma (LUAD)Bladder cancerOsteosarcomaLeukemiaGastric cancerLiver cancerBreast cancerPancreatic ductal adenocarcinomaChromosomal instabilityAneuploidy
04
Safety considerations
Genomic instabilityAneuploidyPremature cellular senescence
05
Biomarkers
Cancer prognosisTumor proliferationTumor invasiveness
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