Buffering of peritoneal pH

Buffering of peritoneal pH is the process by which acid–base balance is maintained in the peritoneal cavity, especially relevant for patients undergoing peritoneal dialysis. During dialysis, fluids are introduced into the peritoneum that require buffering to maintain neutral or physiological pH. This is achieved through the use of buffer compounds such as lactate or bicarbonate in the dialysis solutions. Acidic solutions rapidly equilibrate to blood pH via bidirectional buffer transport across the peritoneal membrane and through local carbonic anhydrase-mediated production of bicarbonate. This process is vital for patient safety and effective dialysis, but is not mediated by a discrete biological target or receptor[1][2][3][5][7]. As such, "buffering of peritoneal pH" is a physiological function rather than a druggable molecular entity. In summary, "Buffering of peritoneal pH" does not refer to a specific, targetable molecule or receptor. It instead describes a physiological process involving multiple molecules (notably buffer compounds and enzymes like carbonic anhydrases), and is not suitable as a canonical molecular target entry[2][3][5][7].

Other names

Regulation of peritoneal pHAcid-base homeostasis in peritoneal dialysis