Burkholderia pseudomallei antigens (B. pseudomallei antigens)

Burkholderia pseudomallei antigens are a collection of surface-exposed and secreted molecules that play critical roles in the pathogenesis of melioidosis, a severe infectious disease (Wiersinga et al., Nature Reviews Microbiology, 2012). Key antigens include the Type I capsular polysaccharide (CPS), which is vital for resisting complement-mediated killing, and the Type II lipopolysaccharide (LPS), which contributes to the inflammatory response (Titball et al., Frontiers in Immunology, 2017). Additionally, proteins such as Hcp1 (Type VI secretion system) and BipD (Type III secretion system) are essential for the bacterium's ability to invade host cells and escape endosomes (Limmathurotsakul et al., Journal of Clinical Microbiology, 2011). These antigens are primary targets for the development of vaccines and monoclonal antibodies, as they can elicit protective immune responses that facilitate bacterial clearance. Because B. pseudomallei is a Tier 1 select agent with high antibiotic resistance, targeting these antigens is a major focus for biodefense and public health research.

Other names

Melioidosis antigensB. pseudomallei surface antigensB. pseudomallei virulence factors

Induction of opsonophagocytic antibodies; neutralization of bacterial secretion systems; inhibition of host cell attachment and invasion; passive immunization via monoclonal antibodies.