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Target intelligence / Profile preview
Butyrophilin subfamily 1 member A1 (BTN1A1)
- Target
- BTN1A1
- Molecular classification
- Immunoglobulin superfamily, Membrane-associated glycoprotein
01
Overview
Butyrophilin subfamily 1 member A1 (BTN1A1) is a membrane-associated glycoprotein belonging to the immunoglobulin superfamily. It plays a crucial role in milk fat droplet secretion and acts as an immune checkpoint molecule, suppressing T-cell activation. It is highly expressed in several solid tumor types, where it contributes to immune evasion. It has also been implicated in the pathogenesis of multiple sclerosis.
- Other names
- BTBTNBTN1butyrophilin subfamily 1 member A1[1][6]
02
Mechanism of action
BTN1A1 blockade enhances antitumor immunity by increasing immune cell infiltration into tumors. It inhibits proliferation of CD4+ and CD8+ T-cells activated by anti-CD3 antibodies; reduces IL2 and IFNG secretion from these cells.
03
Biological functions
Milk fat droplet regulationImmune checkpoint regulationT-cell suppression
04
Disease associations
Multiple sclerosis risk/modulationCancer immune evasion
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