Butyrophilin Subfamily 3 Member A (BTN3A)

Butyrophilin subfamily 3 member A (BTN3A) refers to a family of cell surface proteins, including BTN3A1, BTN3A2, and BTN3A3. These molecules are part of the immunoglobulin superfamily and are closely related to the B7 co-stimulatory family. They play critical roles in immune regulation, particularly in modulating T cell responses and γδ T cell activation. BTN3A acts as an immune checkpoint molecule with implications for cancer prognosis and therapy response prediction.

Other names

CD277BTN3A1BTN3A2BTN3A3CD277aBTF5

Nivolumab binds to PD-1 and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 mediated inhibition of the anti-tumor immune response.