Gosset Molecular Classification
Beta chemokine receptor family, G-protein coupled receptor (GPCR) superfamily, Receptor
Other Names
CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1, Chemokine receptor-like 1 (CHEMR1)
Disease Roles
C-C chemokine receptor 8 Overview
CCR8 is a G-protein coupled receptor (GPCR) that belongs to the beta chemokine receptor family. It mediates chemotaxis and plays a role in immune cell trafficking, particularly in the context of Th2 cells and regulatory T cells. It has emerged as a therapeutic target for cancer immunotherapy and autoimmune diseases.
Mechanism of Action
Blockade or modulation of CCR8-ligand interaction
Biological Functions
Chemotaxis
Regulation of monocyte movement
Apoptosis regulation
T cell positioning/retention
HIV-1 entry into host cells
Disease Associations
Cancer
Autoimmune diseases
HIV infection
Multiple sclerosis
Inflammation
Safety Considerations
- Potential for off-target effects due to chemokine receptor family similarity
- Immunosuppression
- Altered immune cell trafficking
Interacting Drugs
CCL1
CCL8
LMD‑009
ZK 756326
Associated Biomarkers
| Biomarker |
|---|
| CCR8 expression on tumor-infiltrating Tregs |