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Target intelligence / Profile preview
C-C chemokine receptor 8 (CCR8)
- Target
- CCR8
- Molecular classification
- Beta chemokine receptor family, G-protein coupled receptor (GPCR) superfamily, Receptor
01
Overview
CCR8 is a G-protein coupled receptor (GPCR) that belongs to the beta chemokine receptor family. It mediates chemotaxis and plays a role in immune cell trafficking, particularly in the context of Th2 cells and regulatory T cells. It has emerged as a therapeutic target for cancer immunotherapy and autoimmune diseases.
- Other names
- CC-CKR-8CCR-8CDw198CKRL1CMKBR8CMKBRL2CY6GPRCY6TER1Chemokine receptor-like 1 (CHEMR1)
02
Mechanism of action
Blockade or modulation of CCR8-ligand interaction
03
Biological functions
ChemotaxisRegulation of monocyte movementApoptosis regulationT cell positioning/retentionHIV-1 entry into host cells
04
Disease associations
CancerAutoimmune diseasesHIV infectionMultiple sclerosisInflammation
05
Safety considerations
Potential for off-target effects due to chemokine receptor family similarityImmunosuppressionAltered immune cell trafficking
06
Interacting drugs
CCL1
3 more in the full profile.
07
Biomarkers
CCR8 expression on tumor-infiltrating Tregs
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