C-C chemokine receptor type 1 and C-C chemokine receptor type 6 (CCR1 and CCR6)

The target refers to a subset of C-C chemokine receptors, specifically CCR1 and CCR6, expressed on adipose-derived stem cells (ADSCs) that mediate their migration in response to the chemokines MIP-1δ (CCL15) and MIP-3α (CCL20). CCR1 and CCR6 are G protein-coupled receptors that, upon activation, trigger intracellular signaling cascades involving calcium mobilization and MAPK pathways, which are essential for the recruitment of ADSCs to sites of tissue injury or chronic inflammation. In the context of regenerative medicine and oncology, these receptors play a critical role in the homing of mesenchymal stem cells to inflammatory microenvironments, where they can exert immunomodulatory effects or, in some cases, contribute to tumor stroma formation. While these receptors are significant therapeutic targets for inflammatory and autoimmune diseases, the descriptive nature of the input name suggests a composite target rather than a single canonical entity. Pharmacological modulation typically involves small molecule antagonists designed to block the recruitment of inflammatory cells or the mobilization of stem cells to pathological sites.

Other names

CCR1CCR6CD191CD196CKR1CKR6MIP-1 alpha receptorLARC receptor

Antagonism of CCR1 and CCR6 inhibits the G protein-coupled signaling pathways (typically Gi/o) that lead to actin polymerization and directed cell migration (chemotaxis) toward ligand gradients of CCL15 (MIP-1δ) and CCL20 (MIP-3α).