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Target intelligence / Profile preview
Chemokine (C-C motif) Receptor 2 (CCR2)
- Target
- CCR2
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
CCR2 is a G protein-coupled receptor (GPCR) that primarily functions as a receptor for several chemokines, most notably monocyte chemoattractant protein-1 (MCP-1/CCL2). It plays a central role in mediating the migration of monocytes/macrophages and lymphocytes to sites of inflammation. It is implicated in various pathologies including liver disease, cardiovascular disease, CNS disorders, and cancer.
- Other names
- C-C chemokine receptor type 2CD192
02
Mechanism of action
Pharmacological targeting/blockade of either ligands or receptors along the CCL2/CCR2 axis
03
Biological functions
Cell migrationInflammationChemotaxisImmune responseScavenging
04
Disease associations
Liver fibrosisHepatocellular carcinomaCardiovascular diseaseCentral nervous system disordersNeuroinflammationCancerAtherosclerosis
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