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Target intelligence / Profile preview
C-C chemokine receptor type 5
- Molecular classification
- G protein-coupled receptor, Receptor, Chemokine receptor
01
Overview
C-C chemokine receptor type 5 (CCR5), also known as CD195, is a seven-transmembrane G protein-coupled receptor primarily expressed on the surface of various immune cells, including T-lymphocytes, macrophages, dendritic cells, eosinophils, and microglia. It plays a central role in regulating immune cell trafficking and effector functions during inflammatory responses. A critical function of CCR5 is serving as a major co-receptor for R5 strains of HIV‑1/2 entry into host cells. Beyond infectious disease it has implications in cancer, cardiovascular disease and more.
- Other names
- CD195
02
Mechanism of action
CCR5 antagonists block HIV entry by inhibiting interaction between virus envelope proteins and CCR5; inhibition of migration/metastasis in cancer.
03
Biological functions
ChemotaxisImmune responseLeukocyte traffickingImmune modulation
04
Disease associations
HIV/AIDSCancerCardiovascular diseaseInflammation
05
Interacting drugs
Maraviroc
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