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Target intelligence / Profile preview
C-C Motif Chemokine Receptor 7 (CCR7)
- Target
- CCR7
- Molecular classification
- G protein-coupled receptor, Chemokine Receptor, Receptor
01
Overview
CCR7 is a G protein-coupled chemokine receptor crucial for directing immune cell trafficking to secondary lymphoid organs. It plays a significant role in immune surveillance, adaptive immunity, and various pathological conditions like cancer metastasis and chronic inflammatory diseases. CCR7 binds to chemokines CCL19 and CCL21, guiding the migration of T lymphocytes and dendritic cells to lymph nodes. As such, it represents a potential therapeutic target for immunomodulation in cancer, autoimmune disorders, hypertension, and inflammation.
- Other names
- CD197C-C chemokine receptor type 7
02
Mechanism of action
CCR7 antagonists inhibit receptor activation and subsequent immune cell migration.
03
Biological functions
ChemotaxisImmune response regulationCell migrationSignal transduction
04
Disease associations
CancerInflammationRheumatoid arthritisLeukemiaHypertensionAutoimmune Diseases
05
Safety considerations
Potential for broad immune suppressionOff-target effects due to chemokine receptor family similarityRisk of affecting immune surveillance
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