Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
C-C Chemokine Receptor Type 8 (CCR8)
- Target
- CCR8
- Molecular classification
- G protein-coupled receptor, Chemokine receptor, GPCR – Beta chemokine receptors
01
Overview
C-C chemokine receptor type 8 (CCR8) is a G protein-coupled receptor (GPCR) that plays a key role in directing migration of immune cells into inflammatory sites and regulating immune responses, particularly by recruiting regulatory T cells (Tregs) into tumors. It is an attractive target for immuno-oncology therapies aimed at depleting intratumoral Tregs to enhance anti-tumor immunity.
- Other names
- CC-CKR-8CCR-8CDw198CKRL1CMKBR8CMKBRL2CY6GPRCY6TER1
02
Mechanism of action
Direct cytotoxicity against Treg populations or functional antagonism/blockade
03
Biological functions
Immune cell migrationChemotaxisRegulation of inflammationImmune suppressionMonocyte movementThymic cell apoptosisSignal transduction
04
Disease associations
CancerAutoimmune diseasesInflammationInfection
05
Safety considerations
Potential for systemic autoimmunity if peripheral immune regulation is affected
06
Interacting drugs
CCL1
3 more in the full profile.
07
Biomarkers
CCR8 expression levels in tumor-infiltrating Tregs
Beyond the preview
Go deeper on C-C Chemokine Receptor Type 8 (CCR8).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on C-C Chemokine Receptor Type 8 (CCR8).