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Target intelligence / Profile preview
C-C Chemokine Receptor Type 9 (CCR9)
- Target
- CCR9
- Molecular classification
- G protein-coupled receptor, Beta chemokine receptor, Receptor
01
Overview
C-C chemokine receptor type 9 (CCR9) is a seven-transmembrane G protein-coupled receptor that binds to CCL25/TECK. It regulates migration, maturation, proliferation, and apoptosis of leukocytes, particularly T lymphocytes. CCR9 is highly expressed in the thymus, small intestine, and colon and plays a key role in directing immune cell homing to the small intestine. It is implicated in various inflammation-related diseases and cancer.
- Other names
- CDw199GPR-9-6
02
Mechanism of action
Binding of CCL25 (TECK) to CCR9 activates intracellular signaling pathways that increase intracellular calcium levels and promote cell migration.
03
Biological functions
Immune cell traffickingImmune cell homingLeukocyte migrationT lymphocyte maturationLeukocyte proliferationApoptosisSignal transduction
04
Disease associations
Inflammatory bowel diseaseCardiovascular diseaseRheumatoid arthritisHepatitisAsthmaFood allergyAlloimmunityAutoimmunityTransplantation rejectionCancer
05
Safety considerations
Modulation of tissue-specific immunity may have unintended consequences.
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