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Target intelligence / Profile preview
C-C motif chemokine 5 (CCL5)
- Target
- CCL5
- Molecular classification
- Chemokine, CC chemokine
01
Overview
CCL5, also known as RANTES, is a chemokine involved in immune cell recruitment and inflammation. It interacts with receptors such as CCR1, CCR3, CCR4, CCR5, and GPR75, playing roles in viral infections, cancer, asthma, and neurodegenerative diseases. It is considered a therapeutic target for modulating inflammatory responses.
- Other names
- RANTESRegulated upon Activation, Normal T cell Expressed and Secreted
02
Mechanism of action
Receptor binding modulation, leukocyte recruitment modulation, immune response modulation
03
Biological functions
ChemoattractantLeukocyte recruitmentInflammationImmune modulationHistamine releaseEosinophil activation
04
Disease associations
Viral infectionsHIV infectionCancerAsthmaAllergyInflammationNeurodegeneration
05
Safety considerations
Timing of CCL5 modulation is critical for therapeutic outcomesBlocking CCL5 action can impair viral clearance
06
Interacting drugs
Met-RANTES
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