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Target intelligence / Profile preview
C-C motif chemokine ligand 11 (CCL11)
- Target
- CCL11
- Molecular classification
- Chemokine, CC chemokine family, Secreted protein
01
Overview
CCL11, also known as Eotaxin-1, is a chemokine primarily responsible for the recruitment of eosinophils to sites of inflammation. It plays a key role in allergic diseases such as asthma and allergic rhinitis. Elevated levels are also associated with aging, neurodegenerative conditions, psychiatric disorders, and other inflammatory conditions. CCL11 exerts its effects mainly through interaction with the CCR3 receptor, but can also interact with CCR2, CCR5, and CXCR3. It is produced by various cell types, including lymphocytes, macrophages, and epithelial cells, in response to inflammatory stimuli.
- Other names
- EotaxinEotaxin-1Eosinophil chemotactic protein
02
Mechanism of action
N/A
03
Biological functions
ChemotaxisEosinophil recruitmentImmune responseInflammation
04
Disease associations
AsthmaAllergic rhinitisAgingNeurodegenerationCognitive impairmentSchizophreniaChronic traumatic encephalopathy (CTE)Bone inflammationCoronary artery diseaseHIV infection
05
Safety considerations
Systemic CCL11 elevation can impair neurogenesis and cognitive functionMay contribute to blood-brain barrier dysfunction at high concentrations
06
Biomarkers
Asthma severityAgingCognitive declineSchizophreniaChronic traumatic encephalopathy (CTE)Coronary artery disease risk
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