Target intelligence / Profile preview

C-C Motif Chemokine Ligand 21 (CCL21)

Target: CCL21
Molecular classification: CC Chemokine, Cytokine, Ligand

Overview

CCL21 is a CC chemokine that guides CCR7-expressing leukocytes, such as dendritic cells and naïve T-cells, to secondary lymphoid organs. It plays a crucial role in immune cell trafficking, central tolerance, and angiogenesis. CCL21's unique carboxy-terminal tail facilitates binding to extracellular matrix molecules, creating tissue gradients for cell guidance. It is implicated in autoimmune diseases and chronic inflammatory conditions.

Other names: SLCExodus-26CkineSecondary Lymphoid-Tissue Chemokine

Mechanism of action

N/A

Biological functions

ChemotaxisImmune cell homingImmune cell migrationT-cell developmentAngiogenesisRegulation of immune response

Disease associations

Rheumatoid arthritisSjögren's syndromeAutoimmune diseasesInflammation

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