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Target intelligence / Profile preview
C-C motif chemokine ligand 24 (CCL24)
- Target
- CCL24
- Molecular classification
- Chemokine, CC chemokine
01
Overview
CCL24, also known as eotaxin-2, is a small secreted cytokine belonging to the CC chemokine family. It acts primarily as a chemoattractant, strongly inducing migration of eosinophils via interaction with the CCR3 receptor. It is involved in immunoregulatory and inflammatory processes and is implicated in diseases such as asthma, atopic dermatitis, and primary sclerosing cholangitis. Therapeutic targeting of CCL24 or its pathway is being explored for various immune-mediated disorders.
- Other names
- SCYA24Ckb-6MPIF-2myeloid progenitor inhibitory factor 2eotaxin-2eosinophil chemotactic protein 2
02
Mechanism of action
Targets CCL24 axis
03
Biological functions
ChemoattractantEosinophil migrationT lymphocyte migrationImmunoregulationInflammationRegulation of GTPase activityHematopoiesis suppression
04
Disease associations
AsthmaAspirin-exacerbated respiratory disease (AERD)Atopic dermatitisPrimary sclerosing cholangitisRenal inflammationMetabolic dysfunction-associated steatotic liver diseaseSystemic sclerodermaSclerosing cholangitis
05
Interacting drugs
CM-101
06
Biomarkers
Elevated CCL24 levels in plasma (asthma, AERD)CCL24 levels in atopic dermatitisCCL24 levels in primary sclerosing cholangitis
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