C-C motif chemokine ligand 28 (CCL28)

C-C motif chemokine ligand 28 (CCL28) is a member of the CC chemokine family, primarily expressed by epithelial cells in mucosal tissues such as the gut, lung, salivary glands, and breast. CCL28 acts as a chemoattractant for T and B lymphocytes expressing the CCR10 receptor and for eosinophils via CCR3, thereby orchestrating the mucosal recruitment and homing of immune cells. Aside from its chemotactic role, CCL28 has been shown to possess broad-spectrum antimicrobial activity against certain bacteria and fungi. It is constitutively present in mucosal secretions but can be upregulated in inflammation or infection, marking its importance in both innate and adaptive immunity. CCL28 is of growing interest as both a disease biomarker (notably in breast cancer) and a potential therapeutic target in infection, immune-related, and inflammatory conditions[1][2][3][4].

Other names

CCL28Mucosae-associated epithelial chemokineMECCCK1SCYA28Small-inducible cytokine A28Chemokine (C-C motif) ligand 28Protein CCK1Small inducible cytokine subfamily A (Cys-Cys), member 28[1][4]

Chemokine receptor modulation (drugs could modulate interaction with CCR10/CCR3, but none are currently approved) Immunomodulation (potential approach under investigation)[2]