Target intelligence / Profile preview

C-C Motif Chemokine Ligand 4 (CCL4)

Target: CCL4
Molecular classification: Chemokine, Intercrine beta (chemokine CC) family, Ligand

Overview

CCL4 is a chemokine that plays a crucial role in immune cell recruitment and inflammation. It acts as a chemoattractant for various immune cells, primarily through its interaction with the CCR5 receptor. It is also a major HIV-suppressive factor, interfering with HIV entry into CD4+ cells by blocking the CCR5 co-receptor.

Other names: Macrophage Inflammatory Protein-1βMIP-1β

Mechanism of action

CCR5 receptor binding and activation; CCR5 inhibition (in the context of HIV)

Biological functions

Immune cell recruitmentChemotaxisInflammationLymphocyte adhesionRegulation of calcium ion transportAnti-HIV activity

Disease associations

Inflammatory diseasesHIV infectionCardiovascular disease

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