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Target intelligence / Profile preview
C-C Motif Chemokine Ligand 5 (CCL5)
- Target
- CCL5
- Molecular classification
- Chemokine, CC Chemokine
01
Overview
C-C motif chemokine ligand 5 (CCL5), also known as RANTES, is a member of the CC chemokine family. It plays a crucial role in recruiting immune cells to sites of inflammation and is implicated in various diseases, including cancer, cardiovascular disorders, and HIV infection. CCL5 primarily binds to the CCR5 receptor, activating downstream signaling pathways involved in immune responses and inflammation. Its interaction with CCR5 can be targeted therapeutically, as exemplified by the use of maraviroc as a CCR5 antagonist for HIV treatment.
- Other names
- RANTESRegulated upon Activation, Normal T cell Expressed and Secreted
02
Mechanism of action
CCR5 antagonist
03
Biological functions
ChemotaxisImmune cell recruitmentImmune cell activationLeukocyte proliferationLeukocyte survivalApoptosis modulationInflammation
04
Disease associations
Transplant rejectionHIV infectionTumor developmentTumor progressionTumor metastasisCancerCardiovascular diseaseInflammationHypertensionKidney damage
05
Interacting drugs
Maraviroc
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