C-C motif chemokine receptor 10 (CCR10)

C-C motif chemokine receptor 10 is a protein encoded by the CCR10 gene, classified as a class A G protein-coupled receptor that binds chemokines CCL27 and CCL28[1][2][5][7]. It is primarily expressed by melanocytes, plasma cells, and skin-homing T cells, playing a key role in regulating immune cell migration to the skin and inflamed tissues. CCR10 is implicated in skin immunity, inflammatory diseases, and cancer processes, particularly mediating cutaneous T cell responses and metastasis of melanoma to lymph nodes[1]. The receptor is widely recognized as a therapeutic target in immunology and oncology research, with experimental antagonists shown to reduce inflammatory responses in preclinical models[2].

Other names

CCR10GPR2C-C CKR-10CC-CKR-10Chemokine C-C receptor 9

Inhibition of chemokine binding (CCL27, CCL28) to CCR10\nReduction of immune cell migration and inflammatory response