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Target intelligence / Profile preview
C-C Motif Chemokine Receptor 2 (CCR2)
- Target
- CCR2
- Molecular classification
- G protein-coupled receptor
01
Overview
CCR2, also known as CD192, is a G protein-coupled receptor that serves as a high-affinity receptor for several chemokines, most notably CCL2 (MCP-1). It plays critical roles in the immune system and inflammatory processes, particularly in monocyte chemotaxis and migration to inflammatory sites. CCR2 is implicated in various pathological conditions, including inflammatory diseases, liver pathology, cardiovascular disease, neurodegenerative disorders, and metabolic disorders. Due to its involvement in these disease processes, CCR2 has emerged as a potential therapeutic target.
- Other names
- CD192CC chemokine receptor 2
02
Mechanism of action
Inhibition of CCL2/CCR2 axis
03
Biological functions
Monocyte chemotaxisCellular migrationSignal transductionLigand scavenging
04
Disease associations
Inflammatory diseasesLiver pathologyCardiovascular diseaseNeurodegenerative disordersMetabolic disordersRheumatoid arthritisTumorsAcute liver injuryChronic hepatitisFibrosis/cirrhosisTumor progressionAtherosclerosisAlzheimer's diseaseObesity
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