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Target intelligence / Profile preview
C-C motif chemokine receptor 5 mRNA (CCR5 mRNA)
- Target
- CCR5 mRNA
- Molecular classification
- Other (messenger RNA)
01
Overview
CCR5 mRNA is the transcript produced from the CCR5 gene located on chromosome 3, which encodes C-C motif chemokine receptor 5, a G protein-coupled receptor expressed on immune cells and involved in chemokine signaling, cell migration, and functioning as a co-receptor for HIV-1 entry. The abundance, stability, and translation efficiency of CCR5 mRNA regulate CCR5 protein expression and are controlled by several post-transcriptional mechanisms including ribosomal frameshifting, microRNA binding, and nonsense-mediated mRNA decay. While the transcript itself is rarely a therapeutic target, modulation of its level or stability can indirectly affect disease processes such as HIV infection or inflammation.
- Other names
- CCR5 transcriptC-C chemokine receptor type 5 transcriptCCR5 messenger RNA
02
Biological functions
Template for CCR5 protein synthesisRegulation of CCR5 protein expression via mRNA stability and decaySubject to post-transcriptional regulation such as microRNA binding and RNA decay mechanisms
03
Disease associations
Indirectly involved in HIV infection (via encoding CCR5, an essential co-receptor for HIV entry)Indirectly associated with inflammation, cancer, and neurodegeneration (roles stem from CCR5 protein, not the mRNA itself)Variants/mutations (e.g., delta 32 deletion) may affect mRNA expression and downstream disease susceptibility
04
Biomarkers
mRNA abundance as a proxy for CCR5 protein levels in transcriptomics or gene expression profilingdelta 32 variant detection through mRNA analysis
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