Molecular Classification
Neuron, Sensory neuron, Nerve fiber
Other Names
C fibers, Unmyelinated C fibers, Slow-conducting nerve fibers
Disease Roles
Chronic painNeuropathic painInflammatory pain

C-fiber Neuron Overview

C-fiber neurons are a class of unmyelinated nerve fibers found in the peripheral nervous system. They are characterized by their small diameter, lack of myelination, and slow conduction velocity. These fibers play a crucial role in transmitting sensory information related to pain (especially slow, burning pain), temperature, itch, and certain types of touch from the periphery to the central nervous system.

Mechanism of Action

Biological Functions

Nociception
Thermoreception
Mechanoception
Itch sensation
Tactile sensation

Disease Associations

Chronic pain
Neuropathic pain
Inflammatory pain
Itch disorders

Safety Considerations

  • Potential for off-target effects when targeting C-fiber pathways for pain relief.
  • Altered sensation (e.g., reduced pain perception, altered temperature sensitivity) as side effects of therapeutic interventions.