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Target intelligence / Profile preview
c-Jun N-terminal kinase (JNK)
- Target
- JNK
- Molecular classification
- Enzyme, Protein Kinase, MAP Kinase, Serine/Threonine Kinase
01
Overview
c-Jun N-terminal kinases (JNKs) are a subgroup of the mitogen-activated protein kinase (MAPK) family, also known as stress-activated protein kinases (SAPKs). JNKs play a central role in cellular responses to various stress stimuli. They regulate diverse biological processes such as gene expression, neuronal plasticity, cell proliferation and differentiation, apoptosis, inflammation, and cellular senescence. Dysregulation of the pathway has been linked to numerous diseases, including neurodegeneration, metabolic disorders, cancer, and immune disorders, making it an attractive therapeutic target. JNKs are encoded by three genes: MAPK8 (JNK1), MAPK9 (JNK2), and MAPK10 (JNK3). Selective inhibition or modulation of particular isoforms represents a potential therapeutic strategy.
- Other names
- Stress-activated protein kinaseSAPKMAPK8MAPK9MAPK10
02
Mechanism of action
Kinase inhibition/modulation (selective isoform targeting)
03
Biological functions
Signal transductionApoptosisCell proliferationCell differentiationInflammationStress responseGene expression regulationNeuronal plasticityCellular senescence
04
Disease associations
Neurodegenerative diseaseAlzheimer's DiseaseCancerMetabolic disordersObesityDiabetesImmune disordersInfection
05
Safety considerations
Potential for off-target effects due to kinase family similarityContext-dependent pro-survival or pro-apoptotic roles may complicate therapeutic strategies
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