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Target intelligence / Profile preview
c-Jun N-terminal kinase 2 (JNK2)
- Target
- JNK2
- Molecular classification
- Enzyme, Mitogen-Activated Protein Kinase, MAPK, Transcription factor
01
Overview
c-Jun N-terminal kinase 2 (JNK2) is a member of the JNK family, which are part of the MAPK family. JNK2 is activated by various stress stimuli and phosphorylates transcription factors, modulating gene expression. It plays roles in apoptosis, proliferation, differentiation, and is implicated in cancer, neurodegeneration, and immune responses. Targeting the JNK pathway has been proposed as a therapeutic strategy.
- Other names
- MAPK9
02
Mechanism of action
Pharmacological inhibition or genetic silencing can impair tumor growth driven by aberrant Ras/Jnk signaling axes
03
Biological functions
Stress response signalingApoptosisCell proliferationGene expressionCell deathImmune responseDifferentiationSignal transduction
04
Disease associations
CancerNeurodegenerative diseaseImmune dysfunctions
05
Safety considerations
Off-target effects due to JNK isoform cross-reactivityPotential for disrupting normal cellular processes
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