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Target intelligence / Profile preview
Mitogen-activated protein kinase 10 (MAPK10)
- Target
- MAPK10
- Molecular classification
- Enzyme, Protein Kinase, Serine/threonine-specific protein kinase, MAP Kinase
01
Overview
Mitogen-activated protein kinase 10 (MAPK10), also known as c-Jun N-terminal kinase 3 (JNK3), is a member of the MAP kinase family. It is a neuronal-specific JNK isoform involved in various cellular processes, including proliferation, differentiation, transcription regulation, and development. MAPK10 plays regulatory roles in signaling pathways during neuronal apoptosis and is implicated in neurodegenerative diseases and cancer. It is activated by MAP2K4/MKK4 and MAP2K7/MKK7 and phosphorylates transcription factors like JUN and ATF2.
- Other names
- c-Jun N-terminal kinase 3JNK3
02
Biological functions
Signal transductionApoptosisImmune responseCell proliferationCell differentiationTranscription regulationDevelopment
03
Disease associations
Neurodegenerative diseaseOvarian Cancer
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