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Target intelligence / Profile preview
c-KIT Proto-Oncogene Protein (KIT)
- Target
- KIT
- Molecular classification
- Receptor Tyrosine Kinase, Type III Receptor Tyrosine Kinase
01
Overview
The c-KIT proto-oncogene protein is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, differentiation, and migration. It is activated by Stem Cell Factor (SCF) and is essential for various developmental processes. Aberrant activation of KIT, often due to mutations, is implicated in several cancers and other diseases, making it a validated therapeutic target.
- Other names
- Tyrosine-protein kinase KITCD117Mast/stem cell growth factor receptor (SCFR)Proto-oncogene c-KIT
02
Mechanism of action
Small molecule inhibitors of KIT kinase activity
03
Biological functions
Signal transductionCell survivalCell proliferationCell differentiationCell migrationApoptosisHematopoiesisMelanogenesisGametogenesisGastrointestinal motility
04
Disease associations
CancerGastrointestinal stromal tumors (GISTs)Systemic mastocytosisAcute myelogenous leukemiaPiebaldism
05
Safety considerations
Resistance to inhibitors due to secondary mutationsOff-target effects of kinase inhibitorsToxicities associated with chemotherapy-like agents when using less specific inhibitors
06
Interacting drugs
2 more in the full profile.
07
Biomarkers
KIT mutations (e.g., D816V)KIT expression levels
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