C-Maf inducing protein (CMIP)

C-Maf inducing protein (CMIP) is a multifunctional adaptor protein encoded by the CMIP gene on chromosome 16q24[1][3]. It contains domains such as a pleckstrin homology (PH) domain, leucine-rich repeats, and SH3 domain, which support diverse protein interactions. CMIP plays critical roles in T cell signaling and regulation, podocyte cytoskeletal organization in the kidney, and neurodevelopment[1][2][3]. In the immune system, CMIP can inhibit activation and proliferation of T cells and biases cytokine responses. In kidney podocytes, it disrupts cytoskeletal and signaling complexes, contributing to glomerular diseases like minimal change nephrotic syndrome and focal segmental glomerulosclerosis[2]. Overexpression has also been linked to several cancers, where CMIP may promote tumor cell proliferation and migration by modulating pathways such as NF-κB and interaction with proteins like MDM2 and SOX2[1][2]. CMIP’s disease associations extend to neurodevelopmental and metabolic disorders. Because of its pivotal signaling functions and links to disease, CMIP is considered a possible therapeutic target, though no approved drugs or direct modulators are currently known[1][2][3].

Other names

C-Maf-inducing proteinKIAA1694TCMIPc-MipTc-MipTruncated c-Maf-inducing proteintc-MipCMIP