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Target intelligence / Profile preview
c-mesenchymal-epithelial transition factor (c-MET)
- Target
- c-MET
- Molecular classification
- Receptor tyrosine kinase
01
Overview
The c-mesenchymal-epithelial transition factor (c-MET) is a receptor tyrosine kinase involved in cell growth, survival, and motility. It plays a crucial role in embryonic development and tissue regeneration. Aberrant activation of c-MET contributes to tumorigenesis, making it a therapeutic target in various cancers.
- Other names
- METHepatocyte Growth Factor ReceptorHGFR
02
Mechanism of action
Tyrosine kinase inhibitor
03
Biological functions
Cell growthCell survivalCell motilityTissue regenerationOrgan developmentAngiogenesis
04
Disease associations
Cancer
05
Safety considerations
Resistance to therapyOff-target effects of inhibitors
06
Interacting drugs
Crizotinib
07
Biomarkers
MET exon 14 skipping mutationsMET intergenic fusionsMET overexpression
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