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Target intelligence / Profile preview
c-Met Proto-Oncogene Protein (c-Met)
- Target
- c-Met
- Molecular classification
- Receptor, Receptor Tyrosine Kinase, Proto-oncogene
01
Overview
The c-Met proto-oncogene protein, also known as the hepatocyte growth factor receptor (HGFR), is a transmembrane receptor tyrosine kinase that plays a critical role in cellular processes such as proliferation, survival, motility, morphogenesis, and invasion. Aberrant c-Met signaling contributes to tumorigenesis and metastasis across various cancers, making it an important therapeutic target.
- Other names
- Hepatocyte Growth Factor ReceptorHGFR
02
Mechanism of action
Kinase inhibition, receptor blockade, immune-mediated cell killing
03
Biological functions
Cell proliferationCell survivalCell motilityMorphogenesisInvasionSignal transductionEmbryonic developmentTissue regenerationWound healing
04
Disease associations
CancerTumorigenesisMetastasis
05
Safety considerations
Resistance to inhibitorsOff-target effectsDevelopment of alternative signaling pathways
06
Interacting drugs
Small molecule inhibitors targeting kinase activity
3 more in the full profile.
07
Biomarkers
c-Met expression levelsc-Met mutationsc-Met amplification
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