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Target intelligence / Profile preview
c-Met receptor (MET)
- Target
- MET
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
The c-Met receptor, also known as hepatocyte growth factor receptor (HGFR), is a receptor tyrosine kinase that plays a crucial role in cell proliferation, survival, and motility. It is activated by its ligand hepatocyte growth factor (HGF), leading to downstream signaling cascades such as MAPK/RAS, PI3K/AKT, and STAT pathways. Dysregulation of c-Met signaling is implicated in various cancers, making it an important therapeutic target. Aberrant activation can occur through genetic mutations, gene amplification, protein overexpression, or increased HGF expression.
- Other names
- Hepatocyte Growth Factor Receptor (HGFR)proto-oncogene MET
02
Mechanism of action
c-Met inhibitors block the kinase activity of the receptor, preventing downstream signaling.
03
Biological functions
Cell proliferationCell motilityCell survivalEmbryogenesisTissue regenerationWound healingSignal transduction
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to kinase inhibitor promiscuityDevelopment of resistance mechanisms
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