c-Myc-dependent glutaminolysis

c-Myc-dependent glutaminolysis is not a single target molecule but rather a metabolic pathway regulated by the transcription factor c-Myc. This designation is incorrect as it describes a biological process and a regulatory relationship rather than a discrete molecular entity. It represents the metabolic reprogramming where the transcription factor c-Myc drives increased glutamine catabolism in cells, particularly cancer cells. This involves c-Myc's regulation of multiple distinct molecular targets, including Glutaminase 1 (GLS1), glutamine transporters (e.g., SLC1A5/ASCT2, SN2), glutamine synthetase (GS/GLUL), and transaminases (e.g., GOT1, GOT2, GPT2). This pathway supports various cellular functions critical for proliferation, such as NADPH production, TCA cycle anaplerosis, nucleotide synthesis, and non-essential amino acid production. For therapeutic targeting, individual molecular components within this pathway, such as c-Myc itself, GLS1, or SLC1A5, should be considered as distinct targets.