c-myc mRNA

c-myc mRNA is the messenger RNA that encodes the MYC protein, a transcription factor involved in controlling cell growth, proliferation, differentiation, and apoptosis[7][3][5]. Overexpression or dysregulation of c-myc mRNA leads to increased MYC protein production, promoting uncontrolled cell proliferation and cancer development—most notably observed in Burkitt lymphoma and other aggressive cancers[3][7]. Because direct targeting of the MYC protein remains challenging, c-myc mRNA is being studied as a potential therapeutic target, with strategies including antisense oligonucleotides or small interfering RNAs designed to degrade or block the translation of this mRNA transcript[7]. Elevated c-myc mRNA serves as a potential biomarker for the diagnosis, prognosis, and therapeutic stratification of certain cancers, though any therapy modulating its levels must balance anti-tumor efficacy with the risk of disrupting MYC’s physiological functions in normal tissues[6][7][5].

Other names

MYC mRNAMYC transcriptc-Myc messenger RNA

Antisense oligonucleotides or RNA interference: Degradation or inhibition of c-myc mRNA, reducing MYC protein synthesis