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Target intelligence / Profile preview
RAF proto-oncogene serine/threonine-protein kinase (Raf-1)
- Target
- Raf-1
- Molecular classification
- Enzyme, Serine/threonine kinase, Protein kinase
01
Overview
RAF proto-oncogene serine/threonine-protein kinase (Raf-1/c-Raf) is a key enzyme in human cell signaling, encoded by the *RAF1* gene. It is a member of the Raf kinase family and plays a central role in transmitting signals from membrane-associated Ras GTPases to the MAPK/ERK pathway, influencing cell growth, differentiation, and survival. Aberrant c-Raf activity has been implicated in oncogenesis, making it a target for cancer therapy development.
- Other names
- c-RafRAF1
02
Mechanism of action
Inhibition of RAF kinase activity
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalApoptosisCell cycle regulation
04
Disease associations
Cancer
05
Safety considerations
Resistance to RAF inhibitorsOff-target effects
06
Interacting drugs
RAF inhibitors
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