Target intelligence / Profile preview

C-reactive protein (CRP)

Target: CRP
Molecular classification: Pentraxin, Acute-phase protein, Pattern Recognition Receptor

Overview

C-reactive protein (CRP) is a pentameric, ring-shaped protein found in blood plasma. It is an acute-phase reactant whose levels rise rapidly and significantly in response to inflammation, infection, or tissue injury. CRP functions as part of the innate immune system by binding phosphocholine on dead/dying cells or pathogens, triggering the classical complement pathway, and enhancing opsonization and phagocytosis.

Other names: CRPPTX1

Biological functions

Complement activationOpsonizationPhagocytosis enhancementModulation of inflammationInnate immunity

Disease associations

InflammationInfectionCardiovascular diseaseAutoimmune diseasesMalignancy

Biomarkers

InflammationInfectionCardiovascular risk assessment

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