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Target intelligence / Profile preview
C-ros oncogene 1, receptor tyrosine kinase (ROS1)
- Target
- ROS1
- Molecular classification
- Receptor Tyrosine Kinase, Type I integral membrane protein, Insulin receptor family
01
Overview
ROS1 is a receptor tyrosine kinase involved in epithelial cell differentiation and regionalization. Somatic rearrangements leading to fusion proteins containing the ROS1 kinase domain are oncogenic drivers, particularly in non-small cell lung cancer. These fusions activate downstream signaling pathways like RAS-MAPK, PI3K-AKT-mTOR, and JAK-STAT3, promoting cell growth, proliferation, and survival. PD-L1 upregulation following ROS1 fusion activation is relevant for immunotherapy.
- Other names
- ROS1 oncogenec-ros oncogene 1, receptor tyrosine kinase
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Epithelial cell differentiationCell growthCell proliferationCell survivalCell differentiationSignal transduction
04
Disease associations
Cancer
05
Safety considerations
Resistance mutationsIntolerance to crizotinib
06
Interacting drugs
Crizotinib
07
Biomarkers
ROS1 fusionsPD-L1 expression
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