C-terminal domain nuclear envelope phosphatase 1 (CTDNEP1)

CTD nuclear envelope phosphatase 1 (CTDNEP1) is a magnesium-dependent, noncanonical protein serine/threonine phosphatase within the DXDX(T/V) phosphatase family. It forms a membrane protein complex with NEP1R1, its regulatory subunit, to dephosphorylate lipin family proteins and thereby regulate lipid biosynthesis and ER membrane expansion. CTDNEP1 is essential for maintaining proper ER and nuclear envelope morphology; its loss or inactivation leads to excessive ER expansion. Mutations in CTDNEP1 are linked to aggressive childhood medulloblastoma and may play roles in neural development by modulating BMP signaling. The molecular structure of the CTDNEP1–NEP1R1 complex has recently been elucidated, revealing mechanisms of substrate specificity, allosteric regulation, and the basis for cancer-associated mutations[1][2][3][4].

Other names

CTDNEP1DULLARDHSA011916NET56C-terminal domain nuclear envelope phosphatase 1Serine/threonine-protein phosphatase dullardDullard homolog

Drugs targeting this molecule would likely act by modulating its phosphatase activity or the CTDNEP1–NEP1R1 complex's ability to dephosphorylate lipin, thereby affecting ER biogenesis and lipid synthesis[1][2][3]. However, no clinically available drugs with this exact mechanism are listed in the present literature.