Target intelligence / Profile preview

C-terminal Src kinase (Csk)

Target: Csk
Molecular classification: Enzyme, Non-receptor tyrosine-protein kinase

Overview

C-terminal Src kinase (Csk) is a cytosolic, non-receptor tyrosine-protein kinase that negatively regulates Src family kinases (SFKs) by phosphorylating a conserved tyrosine residue at their C-terminus, leading to their inactivation. Csk is involved in numerous cellular processes, including cell growth, differentiation, migration, and immune response. Dysregulation of Csk activity is implicated in cancer and other diseases.

Mechanism of action

Csk phosphorylates Src family kinases at a C-terminal tyrosine residue, leading to their inactivation.

Biological functions

Regulation of cell growth and differentiationCell migrationImmune response modulationAdherens junction organizationBlood coagulationBrain developmentCentral nervous system developmentEpidermal growth factor receptor signaling pathway involvementNegative regulation of ERK1/ERK2 cascadeNegative regulation of kinase activitySignal transduction

Disease associations

CancerNeural tube defectsAutoimmune diseases

Safety considerations

Dysregulation of Csk activity can lead to oncogenesis.Inhibition of Csk may lead to increased Src family kinase activity and related side effects.

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