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C-type lectin domain family 17 member A (CLEC17A)
- Target
- CLEC17A
- Molecular classification
- C-type lectin, Transmembrane receptor, Cell adhesion molecule, Carbohydrate-binding protein
01
Overview
C-type lectin domain family 17 member A (CLEC17A), also known as prolectin, is a type II transmembrane C-type lectin receptor that is mainly expressed on lymph node B cells. It binds fucosylated glycan motifs present on epithelial cells, facilitating cell adhesion—a property leveraged by some tumor cells to colonize lymph nodes during metastasis. CLEC17A possesses a C-type lectin carbohydrate recognition domain with high specificity for mannose and fucose residues, as well as cytoplasmic motifs implicated in intracellular signaling. Sequence and biochemical analyses suggest a possible role in immune regulation beyond cell adhesion, though its full physiological and pathological significance is still under active investigation.
- Other names
- CLEC17AProlectinC-type lectin domain containing 17AFLJ45910prolectin
02
Biological functions
Immune responseCell adhesionSignal transduction
03
Disease associations
CancerInfection
04
Safety considerations
Immune modulationPotential off-target effects typical of lectin-targeted strategies
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