C-type lectin domain family 18 member A (CLEC18A)

C-type lectin domain family 18 member A (CLEC18A) is a secreted C-type lectin receptor highly expressed in human myeloid cells, hepatocytes, and peripheral blood cells[1][2]. It consists of a C-type lectin-like domain (CTLD) and a sperm-coating protein (SCP) domain. CLEC18A acts as a co-receptor for endosomal Toll-like receptor 3 (TLR3), binding viral double-stranded RNA (e.g., poly (I:C)), and enhances production of type I and III interferons during viral infection[2][3]. It inhibits phagocytosis by reducing FcγRIIA levels and affecting autophagosome-lysosome fusion[1]. CLEC18A plays roles in modulating immune responses to viral infections (including HCV and influenza A virus) and is implicated in the pathogenesis of autoimmune complications related to chronic HCV infection, particularly mixed cryoglobulinemia[1][2]. Its glycan-binding specificity and immunoregulatory roles suggest possible biomarker and modulator utility, but there are no approved drugs targeting CLEC18A directly[1][2][3].

Other names

Mannose receptor-like protein 2MRLP2MRCLMRCL1Mannose receptor-like protein 3

For potential therapeutics, modulation of CLEC18A activity could: - Enhance innate immune activation by amplifying TLR3-mediated interferon responses[2][3]. - Influence clearance of immune complexes and modulate inflammation[1].