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C-type lectin domain family 3 member A (CLEC3A)
- Target
- CLEC3A
- Molecular classification
- C-type lectin, Carbohydrate-binding protein, Extracellular matrix protein, Other
01
Overview
C-type lectin domain family 3 member A (CLEC3A) is a **cartilage-specific member** of the C-type lectin superfamily, structurally related to tetranectin. CLEC3A predominantly exists as a monomer but can form dimers and trimers through protein–protein interactions and chondroitin/dermatan sulfate modifications. It is distributed in growth plate cartilage, playing a role in the extracellular matrix network by binding to plasminogen and enhancing tissue plasminogen activator (tPA)-mediated plasminogen activation. This suggests CLEC3A contributes to extracellular proteolytic activity and cartilage remodeling, but it is not a therapeutic target, receptor, enzyme, transporter, or classical drug target[1][2][3].
- Other names
- CLEC3Acartilage-specific lectinChondrolectin
02
Biological functions
Plasminogen activationExtracellular matrix assemblyProtein-protein interactionCartilage biologyOther
03
Disease associations
Other (associated with cartilage function, no direct evidence for roles in cancer, inflammation, etc.)
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