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Target intelligence / Profile preview
C-type lectin domain family 6 member A (CLEC6A)
- Target
- CLEC6A
- Molecular classification
- C-type lectin, Pattern Recognition Receptor, Receptor
01
Overview
CLEC6A, also known as Dectin-2, is a type II transmembrane protein and pattern recognition receptor primarily expressed on macrophages and dendritic cells. It recognizes α-mannans and high-mannose structures present on fungal cell walls and other pathogens, triggering an immune response via the CARD9-Bcl10-Malt1 pathway. CLEC6A is implicated in antifungal immunity and allergic responses to environmental allergens like house dust mites.
- Other names
- Dectin-2CLEC4NCLECSF10hDECTIN-2C-type lectin domain containing 6A
02
Mechanism of action
Ligand binding to CLEC6A triggers signaling through the CARD9-Bcl10-Malt1 pathway, leading to cytokine production and immune cell activation.
03
Biological functions
Pattern recognitionImmune responseCytokine productionAllergic responseCarbohydrate binding
04
Disease associations
CryptococcosisChromoblastomycosisAllergic diseases
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