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Target intelligence / Profile preview
C-type Lectin-Like Molecule-1 (CLL1)
- Target
- CLL1
- Molecular classification
- Receptor, C-type lectin-like receptor, Type II transmembrane glycoprotein
01
Overview
C-type lectin-like molecule-1 (CLL1) is a cell surface receptor primarily expressed on myeloid lineage cells, particularly AML blasts and leukemic stem cells. It functions as an inhibitory immune receptor and is being explored as a therapeutic target in AML due to its limited expression on normal hematopoietic stem cells. CLL1 mediates negative regulation by recruiting phosphatases such as SHP-1/SHP-2 and may participate in activating pathways via PI3K binding.
- Other names
- CLEC12AMyeloid inhibitory C-type lectin-like receptorMICLDendritic cell-associated C-type lectin 2DCAL-2CD371Killer cell lectin like receptor subfamily L member 1KLRL1
02
Mechanism of action
Recruits SHP-1 and SHP-2 phosphatases via ITIM motif to dampen activation signals.
03
Biological functions
Immune signalingInhibitory receptor functionRecruitment of SHP-1 and SHP-2 phosphatases
04
Disease associations
Acute Myeloid Leukemia
05
Safety considerations
Potential for off-target effects on normal myeloid cells (granulocytes/monocytes) expressing CLL1The natural ligand(s) for CLL1 are still undetermined, which could complicate therapeutic interventions
06
Biomarkers
Diagnostic marker for AML blasts and LSCsMinimal residual disease monitoring post-treatment
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