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Target intelligence / Profile preview
C-type lectin-like molecule 1
- Molecular classification
- Lectin, Pattern recognition receptor, Receptor
01
Overview
C-type lectin-like molecule 1 is a member of the C-type lectin domain-containing (CLEC) protein family, characterized by their carbohydrate-recognition domain, which typically binds ligands in a calcium-dependent manner. This group of surface receptors functions primarily in innate and adaptive immunity, mediating the recognition of pathogen- and damage-associated molecular patterns, and can modulate inflammation, cell-cell interactions, and immune signaling pathways. The broad family includes receptors like Dectin-1 (CLEC7A), MINCLE (CLEC4E), CLEC9A, and CLEC12A, each with distinct biological effects in immune cell signaling and homeostasis.
- Other names
- CLEC-1CLEC1C-type lectin domain family 1 member BCLEC1B
02
Mechanism of action
Modulation of immune cell activation Pattern recognition and signaling in response to ligands such as pathogens or damaged cells
03
Biological functions
Immune responseSignal transductionCell adhesion
04
Disease associations
CancerInflammationInfectionCardiovascular disease
05
Safety considerations
Potential for immunomodulatory side effects; targeting CLRs may result in altered immune responses and increased infection or autoimmunity risks
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