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C-type lectin-like type II transmembrane protein NKG2A (NKG2A)

Target: NKG2A
Molecular classification: Type II transmembrane glycoprotein, C-type lectin-like receptor, Receptor

Overview

NKG2A is an inhibitory receptor expressed on NK cells and a subset of CD8+ T cells. It forms a heterodimer with CD94 and recognizes HLA-E, a non-classical MHC class I molecule. Engagement of NKG2A leads to recruitment of phosphatases that suppress activating signaling cascades, preventing inappropriate activation against healthy cells. NKG2A blockade or modulation has therapeutic potential for enhancing antitumor immunity or treating autoimmune diseases.

Other names: Killer cell lectin-like receptor subfamily C member 1KLRC1

Mechanism of action

Inhibition of NK/T cell activation and cytotoxicity via ITIM signaling and recruitment of SHP-1/SHP-2 phosphatases.

Biological functions

Immune checkpointInhibitory receptor signalingRegulation of NK cell activityRegulation of T cell activitySelf-tolerance

Disease associations

CancerAutoimmunityInfectionTransplantation

Safety considerations

Potential for immune-related adverse events with NKG2A blockade.

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