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Target intelligence / Profile preview
C-X-C Chemokine Receptor Type 1 (CXCR1)
- Target
- CXCR1
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
CXCR1 is a G-protein-coupled receptor and a high-affinity receptor for interleukin-8 (IL-8, CXCL8). It is predominantly expressed on neutrophils and plays a critical role in neutrophil chemotaxis, activation, and inflammatory responses. It also contributes to angiogenesis and tumor growth, making it a therapeutic target for various diseases including cancer and inflammatory disorders.
- Other names
- Interleukin 8 receptor alphaIL8RACD181CD128CKR-1CMKAR1
02
Mechanism of action
Inhibition/blockade of CXCR1 to reduce neutrophil recruitment and inflammatory responses; prevention of angiogenesis and tumor growth.
03
Biological functions
Neutrophil chemotaxisNeutrophil activationInflammationAngiogenesisImmune cell recruitmentSignal transduction
04
Disease associations
Inflammatory diseasesCancerAutoimmune disordersAcute respiratory distress syndrome (ARDS)Leukemia
05
Safety considerations
Potential for off-target effects due to similarity with CXCR2Risk of immunosuppression if neutrophil function is excessively inhibited
06
Biomarkers
Expression levels in breast cancer tissue samples for malignancy risk
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